Art historians have deduced in that singularly mysterious visage everything from a cross-dressing self-portrait of Leonardo da Vinci to the knowing glance of an unfaithful wife to the satisfied pride of a pregnant woman. Bob Dylan once even offered up a very 20th century American conclusion on the matter: "Mona Lisa must've had the highway blues." A Sicilian professor of pathological anatomy has come up with the latest and what is arguably the least poetic explanation imaginable for why Mona Lisa looks the way she does: high cholesterol.

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